Two-stage case-control association study of dopamine-related genes and migraine.

ABSTRACT:

Background

We previously reported risk haplotypes for two genes related with serotonin and dopamine metabolism: MAOA in migraine without aura and DDC in migraine with aura. Herein we investigate the contribution to migraine susceptibility of eight additional genes involved in dopamine neurotransmission.

Methods

We performed a two-stage case-control association study of 50 tag single nucleotide polymorphisms (SNPs), selected according to genetic coverage parameters. The first analysis consisted of 263 patients and 274 controls and the replication study was composed by 259 cases and 287 controls. All cases were diagnosed according to ICHD-II criteria, were Spanish Caucasian, and were sex-matched with control subjects.

Results

Single-marker analysis of the first populati

SUBMITTER: Corominas R 

PROVIDER: S-EPMC2758864 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature