In Silico screening for functional candidates amongst hypothetical proteins.

ABSTRACT:

Background

The definition of a hypothetical protein is a protein that is predicted to be expressed from an open reading frame, but for which there is no experimental evidence of translation. Hypothetical proteins constitute a substantial fraction of proteomes of human as well as of other eukaryotes. With the general belief that the majority of hypothetical proteins are the product of pseudogenes, it is essential to have a tool with the ability of pinpointing the minority of hypothetical proteins with a high probability of being expressed.

Results

Here, we present an in silico selection strategy where eukaryotic hypothetical proteins are sorted according to two criteria that can be reliably identified in silico: the presence of subcellular targeting signals and presence of ch

SUBMITTER: Desler C 

PROVIDER: S-EPMC2758874 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature