Stability of metabolic correlations under changing environmental conditions in Escherichia coli--a systems approach.

ABSTRACT:

Background

Biological systems adapt to changing environments by reorganizing their cellular and physiological program with metabolites representing one important response level. Different stresses lead to both conserved and specific responses on the metabolite level which should be reflected in the underlying metabolic network.

Methodology/principal findings

Starting from experimental data obtained by a GC-MS based high-throughput metabolic profiling technology we here develop an approach that: (1) extracts network representations from metabolic condition-dependent data by using pairwise correlations, (2) determines the sets of stable and condition-dependent correlations based on a combination of statistical significance and homogeneity tests, and (3) can identify metabolite

SUBMITTER: Szymanski J 

PROVIDER: S-EPMC2759078 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature