Genomic loci modulating the retinal transcriptome in wound healing.

ABSTRACT:

Purpose

The present study predicts and tests genetic networks that modulate gene expression during the retinal wound-healing response.

Methods

Upstream modulators and target genes were defined using meta-analysis and bioinformatic approaches. Quantitative trait loci (QTLs) for retinal acute phase genes (Vazquez-Chona et al. 2005) were defined using QTL analysis of CNS gene expression (Chesler et al. 2005). Candidate modulators were defined using computational analysis of gene and motif sequences. The effect of candidate genes on wound healing was tested using animal models of gene expression.

Results

A network of early wound-healing genes is modulated by a locus on chromosome 12. The genetic background of the locus altered the wound-healing response of the retina. The

SUBMITTER: Vazquez-Chona FR 

PROVIDER: S-EPMC2759132 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature