Syntheses and biological activity studies of novel sterol analogs from nitroso Diels-Alder reactions of ergosterol.

ABSTRACT: A series of novel sterol analogs was prepared using nitroso Diels-Alder reactions with ergosterol. Most cycloaddition reactions proceeded in an excellent regio- and stereoselective fashion. Further N-O bond cleavage of cycloadducts generated compounds with biological activity in PC-3 and MCF-7 cancer cell lines.

SUBMITTER: Yang B 

PROVIDER: S-EPMC2759323 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature