Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type.

ABSTRACT:

Background

Cerebrospinal fluid (CSF) levels of Abeta peptide 1-42 (Abeta 42), tau, and phosphorylated tau (ptau) are potential biomarkers of Alzheimer disease.

Objective

To determine whether Abeta 42, tau, and ptau predict the rate of cognitive change in individuals with very mild dementia of the Alzheimer type (DAT).

Design

Retrospective analysis of CSF biomarkers and clinical data.

Setting

An academic Alzheimer disease research center.

Participants

Research volunteers in a longitudinal study of aging and cognition. Participants (n = 49) had a clinical diagnosis of very mild DAT with a Clinical Dementia Rating (CDR) of 0.5 at the time of lumbar puncture. All the participants had at least 1 follow-up assessment (mean [SD] follow-up, 3.5 [1.8] years).

SUBMITTER: Snider BJ 

PROVIDER: S-EPMC2759394 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature