4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

ABSTRACT: Dietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila. A number of nuclear encoded mitochondrial genes, including those in Complex I and IV of the electron transport chain, showed increased ribosomal loading and enhanced overall activity upon DR. We found that various mitochondrial genes possessed shorter and less structured 5'UTRs, which were important for their enhanced mRNA translation. The translational repressor 4E-BP, the eukaryotic translation initiation factor 4E binding protein, was upregulated upon DR and mediated DR dependent changes in mitochondrial activity and lifespan extension. Inhibition of individual mitochondrial subunits from Complex I and IV dimi

SUBMITTER: Zid BM 

PROVIDER: S-EPMC2759400 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature