Probe-level analysis of expression microarrays characterizes isoform-specific degradation during mouse oocyte maturation.

ABSTRACT:

Background

Gene expression microarrays have provided many insights into changes in gene expression patterns between different tissue types, developmental stages, and disease states. Analyses of these data focused primarily measuring the relative abundance of transcripts of a gene, while treating most or all transcript isoforms as equivalent. Differences in the selection between transcript isoforms can, however, represent critical changes to either the protein product or the posttranscriptional regulation of the transcript. Novel analyses on existing microarray data provide fresh insights and new interpretations into transcriptome-wide changes in expression.

Methodology

A probe-level analysis of existing gene expression arrays revealed differences in mRNA processing, primaril

SUBMITTER: Salisbury J 

PROVIDER: S-EPMC2759528 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature