Ontology highlight
ABSTRACT:
SUBMITTER: Brydges SD
PROVIDER: S-EPMC2759865 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Brydges Susannah D SD Mueller James L JL McGeough Matthew D MD Pena Carla A CA Misaghi Amirhossein A Gandhi Chhavi C Putnam Chris D CD Boyle David L DL Firestein Gary S GS Horner Anthony A AA Soroosh Pejman P Watford Wendy T WT O'Shea John J JJ Kastner Daniel L DL Hoffman Hal M HM
Immunity 20090604 6
NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response to IL-1-targeted therapy. We developed two Nlrp3 mutant knockin mouse strains to model CAPS to examine the role of other inflammatory mediators and adaptive immune responses in an in ...[more]