Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses.

ABSTRACT:

Background

Purely epistatic multi-locus interactions cannot generally be detected via single-locus analysis in case-control studies of complex diseases. Recently, many two-locus and multi-locus analysis techniques have been shown to be promising for the epistasis detection. However, exhaustive multi-locus analysis requires prohibitively large computational efforts when problems involve large-scale or genome-wide data. Furthermore, there is no explicit proof that a combination of multiple two-locus analyses can lead to the correct identification of multi-locus interactions.

Results

The proposed 2LOmb algorithm performs an omnibus permutation test on ensembles of two-locus analyses. The algorithm consists of four main steps: two-locus analysis, a permutation test, global p-val

SUBMITTER: Wongseree W 

PROVIDER: S-EPMC2759961 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature