Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation.

ABSTRACT:

Background

Synapse formation and the development of neural networks are known to be controlled by a coordinated program of mRNA synthesis. microRNAs are now recognized to be important regulators of mRNA translation and stability in a wide variety of organisms. While specific microRNAs are known to be involved in neural development, the extent to which global microRNA and mRNA profiles are coordinately regulated in neural development is unknown.

Results

We examined mouse primary neuronal cultures, analyzing microRNA and mRNA expression. Three main developmental patterns of microRNA expression were observed: steady-state levels, up-regulated and down-regulated. Co-expressed microRNAs were found to have related target recognition sites and to be encoded in distinct genomic loca

SUBMITTER: Manakov SA 

PROVIDER: S-EPMC2759968 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature