Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders.

ABSTRACT:

Purpose of review

Although it may seem paradoxical, primary immunodeficiency disorders are frequently complicated by autoimmune and inflammatory conditions. These conditions pose significant diagnostic and therapeutic challenges for clinicians caring for these patients. There have been a number of new insights into how immunodeficiencies can predispose to autoimmunity, and rheumatologists should understand the basis for and manifestations of autoimmunity in primary immunodeficiency disorders to more effectively care for these patients.

Recent findings

A number of mechanisms have recently been found to link primary immunodeficiencies and autoimmunity, including increased homeostatic proliferation in primary immunodeficiencies associated with lymphopenia and defects in regulat

SUBMITTER: Goyal R 

PROVIDER: S-EPMC2760066 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature