Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma.

ABSTRACT:

Aim

To identify biomarkers indicating virus-specific hepatocarcinogenic process, differential mRNA expression in 32 patients with hepatitis B virus (HBV)-/hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) were investigated by means of cDNA microarrays comprising of 886 genes.

Methods

Thirty two HCC patients were divided into two groups based on viral markers: hepatitis B virus positive and HCV positive. The expression profiles of 32 pairs of specimens (tumorous and surrounding non-tumorous liver tissues), consisting of 886 genes were analyzed.

Results

Seven up-regulated genes in HBV-associated HCC comprised genes involved in protein synthesis (RPS5), cytoskeletal organization (KRT8), apoptosis related genes (CFLAR), transport (ATP5F1), cell membrane re

SUBMITTER: Lee CF 

PROVIDER: S-EPMC2760187 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature