Torque teno virus: its prevalence and isotypes in North India.

ABSTRACT:

Aim

To investigate the prevalence and genotype distribution of Torque teno virus (TTV) in patients with different liver diseases and chronic renal failure treated at a referral hospital in North India.

Methods

Whereas prevalence of TTV was based on amplification of conserved region of ORF2 of TTV genome, the genotyping of TTV was carried out using restriction fragment length polymorphism (RFLP) procedure on the N22 region of ORF1.

Results

TTV-DNA was detected in 137 of 513 (26.7%) patients with liver diseases and 38 of 65 (58.5%) patients with chronic renal failure. TTV was also detected in 27% of healthy controls. The sequence analysis of the PCR product from 10 randomly selected cases failed to show a significant sequence divergence when compared with that of the TR

SUBMITTER: Irshad M 

PROVIDER: S-EPMC2760200 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature