Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation.

ABSTRACT:

Background

The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.

Methods

LCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.

Results

There were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expre

SUBMITTER: Martin MV 

PROVIDER: S-EPMC2760574 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature