Neonatal and adult O4(+) oligodendrocyte lineage cells display different growth factor responses and different gene expression patterns.

ABSTRACT: Oligodendrocytes are the myelinating cells of the central nervous system. Although the CNS possesses the ability to repair demyelinating insults, in certain cases, such as the chronic lesions found in multiple sclerosis, remyelination fails. Cycling cells capable of becoming oligodendrocytes have been identified in both the developing and the adult mammalian forebrain. Many studies have focused on differences in gene expression profiles as oligodendrocyte progenitors differentiate into myelinating oligodendrocytes by isolating cells at different developmental stages from animals at a single age. However, few have studied the differences that exist between the progenitors of the neonatal CNS and those of the adult CNS. This study examined the response of neonatal and adult O4(+) cells to pl

SUBMITTER: Lin G 

PROVIDER: S-EPMC2760623 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature