Genome-wide identification of allelic expression in hypertensive rats.

ABSTRACT:

Background

Identification of genes involved in complex cardiovascular disease traits has proven challenging. Inbred animal models can facilitate genetic studies of disease traits. The spontaneously hypertensive rat (SHR) is an inbred model of hypertension that exists in several closely related but genetically distinct lines.

Methods and results

We used renal gene-expression profiling across 3 distinct SHR lines to identify genes that show different expression in SHR than in the genetically related normotensive control strain, Wistar-Kyoto. To ensure robust discovery of genes showing SHR-specific expression differences, we considered only those genes in which differential expression is replicated in multiple animals of each of multiple hypertensive rat lines at multiple time

SUBMITTER: Dmitrieva RI 

PROVIDER: S-EPMC2760851 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature