Inhibitors of factor VIII in black patients with hemophilia.

ABSTRACT:

Background

Black patients with hemophilia A (factor VIII deficiency) are twice as likely as white patients to produce inhibitors against factor VIII proteins given as replacement therapy. There are six wild-type factor VIII proteins, designated H1 through H6, but only two (H1 and H2) match the recombinant factor VIII products used clinically. H1 and H2 are found in all racial groups and are the only factor VIII proteins found in the white population to date. H3, H4, and H5 have been found only in blacks. We hypothesized that mismatched factor VIII transfusions contribute to the high incidence of inhibitors among black patients.

Methods

We sequenced the factor VIII gene (F8) in black patients with hemophilia A to identify causative mutations and the background haplotypes on w

SUBMITTER: Viel KR 

PROVIDER: S-EPMC2761028 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature