A HIV-1 heterosexual transmission chain in Guangzhou, China: a molecular epidemiological study.

ABSTRACT:

Background

We conducted molecular analyses to confirm four clustering HIV-1 infections (Patient A, B, C & D) in Guangzhou, China. These cases were identified by epidemiological investigation and suspected to acquire the infection through a common heterosexual transmission chain.

Methods

Env C2V3V4 region, gag p17/p24 junction and partial pol gene of HIV-1 genome from serum specimens of these infected cases were amplified by reverse transcription polymerase chain reaction (RT-PCR) and nucleotide sequenced.

Results

Phylogenetic analyses indicated that their viral nucleotide sequences were significantly clustered together (bootstrap value is 99%, 98% and 100% in env, gag and pol tree respectively). Evolutionary distance analysis indicated that their genetic diversities o

SUBMITTER: Han Z 

PROVIDER: S-EPMC2761389 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature