Pleiotropic effects of neutrophils on myocyte apoptosis and left ventricular remodeling during early volume overload.

ABSTRACT: Most of the available evidence on the role of neutrophils on pathological cardiac remodeling has been pertained after acute myocardial infarction. However, whether neutrophils directly contribute to the pathogenesis of cardiac remodeling after events other than acute myocardial infarction remains unknown. Here we show that acute eccentric hypertrophy induced by aorto-caval fistula (ACF) in the rats induced an increase in the inflammatory response characterized by activation of the STAT pathway and increased infiltration of neutrophils in the myocardium. This early inflammation was associated with a decrease in interstitial collagen accumulation and an increase in myocyte apoptosis. Neutrophil infiltration blockade attenuated MMP activation, ECM degradation, and myocyte apoptosis induced by

SUBMITTER: Kolpakov MA 

PROVIDER: S-EPMC2761535 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature