Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma.

ABSTRACT:

Aim

To investigate the expression of Neurensin-2 (NRSN2) in hepatocellular carcinoma (HCC) and its prognostic values in predicting survival.

Methods

The expression and prognostic significance of NRSN2 in HCC was examined by performing immunohistochemical analysis using a total of 110 HCC clinical tissue samples, and Western blotting analysis to further confirm the result.

Results

Decreased NRSN2 expression was shown in 70.9% cases. Loss of NRSN2 expression in HCC was significantly related to tumor size (P = 0.006). Larger tumor size was related to negative expression of NRSN2. Patients showing negative NRSN2 expression had a significantly shorter overall survival than those with positive expression (P = 0.008). Multivariate Cox regression analysis indicated that NRSN2

SUBMITTER: Ma HQ 

PROVIDER: S-EPMC2761566 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature