P53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content.

ABSTRACT:

Rationale

Exercise capacity is a physiological characteristic associated with protection from both cardiovascular and all-cause mortality. p53 regulates mitochondrial function and its deletion markedly diminishes exercise capacity, but the underlying genetic mechanism orchestrating this is unclear. Understanding the biology of how p53 improves exercise capacity may provide useful insights for improving both cardiovascular as well as general health.

Objective

The purpose of this study was to understand the genetic mechanism by which p53 regulates aerobic exercise capacity.

Methods and results

Using a variety of physiological, metabolic, and molecular techniques, we further characterized maximum exercise capacity and the effects of training, measured various nonmitochon

SUBMITTER: Park JY 

PROVIDER: S-EPMC2761626 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature