The endo-siRNA pathway is essential for robust development of the Drosophila embryo.

ABSTRACT:

Background

Robustness to natural temperature fluctuations is critical to proper development in embryos and to cellular functions in adult organisms. However, mechanisms and pathways which govern temperature compensation remain largely unknown beyond circadian rhythms. Pathways which ensure robustness against temperature fluctuations may appear to be nonessential under favorable, uniform environmental conditions used in conventional laboratory experiments where there is little variation for which to compensate. The endo-siRNA pathway, which produces small double-stranded RNAs in Drosophila, appears to be nonessential for robust development of the embryo under ambient uniform temperature and to be necessary only for viral defense. Embryos lacking a functional endo-siRNA pathway devel

SUBMITTER: Lucchetta EM 

PROVIDER: S-EPMC2761733 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature