A methodology for the analysis of differential coexpression across the human lifespan.

ABSTRACT:

Background

Differential coexpression is a change in coexpression between genes that may reflect 'rewiring' of transcriptional networks. It has previously been hypothesized that such changes might be occurring over time in the lifespan of an organism. While both coexpression and differential expression of genes have been previously studied in life stage change or aging, differential coexpression has not. Generalizing differential coexpression analysis to many time points presents a methodological challenge. Here we introduce a method for analyzing changes in coexpression across multiple ordered groups (e.g., over time) and extensively test its validity and usefulness.

Results

Our method is based on the use of the Haar basis set to efficiently represent changes in coexpression

SUBMITTER: Gillis J 

PROVIDER: S-EPMC2761903 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature