Association of common variants in mismatch repair genes and breast cancer susceptibility: a multigene study.

ABSTRACT:

Background

MMR is responsible for the repair of base-base mismatches and insertion/deletion loops. Besides this, MMR is also associated with an anti-recombination function, suppressing homologous recombination. Losses of heterozygosity and/or microsatellite instability have been detected in a large number of skin samples from breast cancer patients, suggesting a potential role of MMR in breast cancer susceptibility.

Methods

We carried out a hospital-based case-control study in a Caucasian Portuguese population (287 cases and 547 controls) to estimate the susceptibility to non-familial breast cancer associated with some polymorphisms in mismatch repair genes (MSH3, MSH4, MSH6, MLH1, MLH3, PMS1 and MUTYH).

Results

Using unconditional logistic regression we found that ML

SUBMITTER: Conde J 

PROVIDER: S-EPMC2761943 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature