Crossed intermolecular [2+2] cycloadditions of acyclic enones via visible light photocatalysis.

ABSTRACT: Efficient [2+2] heterodimerizations of dissimilar acyclic enones can be accomplished upon visible light irradiation in the presence of a ruthenium(II) photocatalyst. Similar cycloadditions under standard UV photolysis conditions are inefficient and unselective. Nevertheless, a diverse range of unsymmetrical tri- and tetrasubstituted cyclobutane structures can be produced in good yields and excellent diastereoselectivities using this new method. The reaction is promoted by any visible light source, and efficient, gram-scale cycloadditions can be conducted upon irradiating with ambient sunlight.

SUBMITTER: Du J 

PROVIDER: S-EPMC2761970 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature