An eight-gene blood expression profile predicts the response to infliximab in rheumatoid arthritis.

ABSTRACT:

Background

TNF alpha blockade agents like infliximab are actually the treatment of choice for those rheumatoid arthritis (RA) patients who fail standard therapy. However, a considerable percentage of anti-TNF alpha treated patients do not show a significant clinical response. Given that new therapies for treatment of RA have been recently approved, there is a pressing need to find a system that reliably predicts treatment response. We hypothesized that the analysis of whole blood gene expression profiles of RA patients could be used to build a robust predictor to infliximab therapy.

Methods and findings

We performed microarray gene expression analysis on whole blood RNA samples from RA patients starting infliximab therapy (n = 44). The clinical response to infliximab was det

SUBMITTER: Julia A 

PROVIDER: S-EPMC2762038 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature