Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial.

ABSTRACT:

Background

Isoflavones are naturally occurring plant estrogens that are abundant in soy. Although purported to protect against bone loss, the efficacy of soy isoflavone supplementation in the prevention of osteoporosis in postmenopausal women remains controversial.

Objective

Our aim was to test the effect of soy isoflavone supplementation on bone health.

Design

A multicenter, randomized, double-blind, placebo-controlled 24-mo trial was conducted to assess the effects of daily supplementation with 80 or 120 mg of soy hypocotyl aglycone isoflavones plus calcium and vitamin D on bone changes in 403 postmenopausal women. Study subjects were tested annually and changes in whole-body and regional bone mineral density (BMD), bone mineral content (BMC), and T scores were asse

SUBMITTER: Wong WW 

PROVIDER: S-EPMC2762163 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature