Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells.

ABSTRACT:

Background

MicroRNAs (miRNAs) are a class of small non-coding RNAs that have recently emerged as important regulators of gene expression. They negatively regulate gene expression post-transcriptionally by translational repression and target mRNA degradation. miRNAs have been shown to play crucial roles in muscle development and in regulation of muscle cell proliferation and differentiation.

Methodology/principal findings

By comparing miRNA expression profiling of proliferating myoblasts versus differentiated myotubes, a number of modulated miRNAs, not previously implicated in regulation of myogenic differentiation, were identified. Among these, miR-221 and miR-222 were strongly down-regulated upon differentiation of both primary and established myogenic cells. Conversely, mi

SUBMITTER: Cardinali B 

PROVIDER: S-EPMC2762614 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature