DRD2-related TaqIA polymorphism modulates motivation to smoke.

ABSTRACT:

Introduction

TaqIA polymorphism, a genetic variant associated with the expression level of dopamine D2 receptors in the brain, has been linked to various aspects of smoking behavior, including smoking prevalence, affective withdrawal symptoms, and smoking cessation outcome. However, its involvement in motivation to smoke cigarettes has not been elucidated.

Methods

The present study examined the possible differences in self-reported reasons to smoke and craving for smoking in 160 smokers participating in a clinical trial.

Results

Individuals with at least one A1 allele of the TaqIA polymorphism were more likely to report smoking for stimulating effects and to reduce negative affect compared with those lacking an A1 allele. The association of the A1 genotype with a high

SUBMITTER: Zuo Y 

PROVIDER: S-EPMC2762931 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature