Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ.

ABSTRACT:

Background

Autofluorescence bronchoscopy is more sensitive than conventional bronchoscopy for detecting early airway mucosal lesions. Decreased specificity can lead to excessive biopsy and increased procedural time. Onco-LIFE, a device that combines fluorescence and reflectance imaging, allows numeric representation by expressing red-to-green ratio (R/G ratio) within the region of interest. The aim of the study was to determine if color fluorescence ratio (R/G ratio) added to autofluorescence bronchoscopy could provide an objective means to guide biopsy.

Methods

Subjects at risk for lung cancer were recruited at two centers: VU University Medical Centre (Amsterdam) and BC Cancer Agency (Canada). R/G ratio for each site appearing normal or abnormal was measured before biopsy.

SUBMITTER: Lee P 

PROVIDER: S-EPMC2762942 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature