Obesity is associated with atypia in breast ductal lavage of women with proliferative breast disease.

ABSTRACT:

Background

Benign proliferative breast disease without atypia slightly increases breast cancer risk but there are currently few clinical options for breast cancer prevention in this group of women.

Methods

We conducted a pilot study of women with a past diagnosis of proliferative breast disease with a goal to determine if the characteristics of cells obtained by breast ductal lavage were related to nutritional factors.

Results

There were 57 women who enrolled. A total of 39 women yielded nipple aspirate fluid (NAF) samples and 36 underwent breast ductal lavage. Five of the lavage samples were acellular and 28 had at least 200 cells. Surprisingly, atypia was present in 11 women. Presence of atypia was associated with slight changes in morphometric features of the epith

SUBMITTER: Djuric Z 

PROVIDER: S-EPMC2763034 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature