Prospective association between C-reactive protein and fatigue in the coronary artery risk development in young adults study.

ABSTRACT:

Background

Fatigue is highly prevalent and causes serious disruption in quality of life. Although the underlying biological mechanism is unknown, increases in inflammation have been implicated. This prospective study examined the association between C-reactive protein (CRP), a biomarker of systemic inflammation, and fatigue 5 years later.

Methods

The Coronary Artery Risk Development in Young Adults (CARDIA) study is a population-based longitudinal study conducted in four U.S. cities. Highly sensitive CRP concentration and fatigue were measured in 2983 African American and white adults at both year 15 (2000-2001, ages 33-45 years) and year 20 (2005-2006) examinations. Fatigue was assessed using the vitality subscale of the 12-item Short Form Health Survey.

Results

Plas

SUBMITTER: Cho HJ 

PROVIDER: S-EPMC2763037 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature