Gold-catalyzed [3+3]-annulation of azomethine imines with propargyl esters.

ABSTRACT: The gold-catalyzed [3+3]-cycloaddition reaction of propargyl esters and azomethine imines has been developed. The reaction provides a rapid entry into a wide range of substituted tetrahydropyridazine derivatives from simple starting materials. A stepwise mechanism involving addition of the 1,3-dipole to a gold-carbenoid intermediate is proposed.

SUBMITTER: Shapiro ND 

PROVIDER: S-EPMC2763378 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature