Alterations in transmural myocardial strain: an early marker of left ventricular dysfunction in mitral regurgitation?

ABSTRACT:

Background

In asymptomatic patients with severe isolated mitral regurgitation (MR), identifying the onset of early left ventricular (LV) dysfunction can guide the timing of surgical intervention. We hypothesized that changes in LV transmural myocardial strain represent an early marker of LV dysfunction in an ovine chronic MR model.

Methods and results

Sheep were randomized to control (CTRL, n=8) or experimental (EXP, n=12) groups. In EXP, a 3.5- or 4.8-mm hole was created in the posterior mitral leaflet to generate "pure" MR. Transmural beadsets were inserted into the lateral and anterior LV wall to radiographically measure 3-dimensional transmural strains during systole and diastolic filling, at 1 and 12 weeks postoperatively. MR grade was higher in EXP than CTRL at 1 and 1

SUBMITTER: Carlhall CJ 

PROVIDER: S-EPMC2763536 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature