A new equation to estimate glomerular filtration rate.

ABSTRACT:

Background

Equations to estimate glomerular filtration rate (GFR) are routinely used to assess kidney function. Current equations have limited precision and systematically underestimate measured GFR at higher values.

Objective

To develop a new estimating equation for GFR: the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.

Design

Cross-sectional analysis with separate pooled data sets for equation development and validation and a representative sample of the U.S. population for prevalence estimates.

Setting

Research studies and clinical populations ("studies") with measured GFR and NHANES (National Health and Nutrition Examination Survey), 1999 to 2006.

Participants

8254 participants in 10 studies (equation development data set) and

SUBMITTER: Levey AS 

PROVIDER: S-EPMC2763564 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature