Reciprocal interactions between commensal bacteria and gamma delta intraepithelial lymphocytes during mucosal injury.

ABSTRACT: The intestinal mucosal surface is in direct contact with a vast beneficial microbiota. The symbiotic nature of this relationship is threatened when the surface epithelium is injured, yet little is known about how mucosal surfaces maintain homeostasis with commensal microbes following damage. Gammadelta intraepithelial lymphocytes (gammadelta IEL) reside at the gut epithelial surface, where they stimulate mucosal healing following acute injury. A genome-wide analysis of the gammadelta IEL response to dextran sulfate sodium-induced colonic damage revealed induction of a complex transcriptional program, including coordinate regulation of cytoprotective, immunomodulatory, and antibacterial factors. Studies in germfree mice demonstrated that commensal microbiota regulate key components of this

SUBMITTER: Ismail AS 

PROVIDER: S-EPMC2763635 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature