Transcriptional regulation of mammalian selenoprotein expression.

ABSTRACT:

Background

Selenoproteins contain the twenty-first amino acid, selenocysteine, and are involved in cellular defenses against oxidative damage, important metabolic and developmental pathways, and responses to environmental challenges. Elucidating the mechanisms regulating selenoprotein expression at the transcriptional level is a key to understanding how these mechanisms are called into play to respond to the changing environment.

Methods

This review summarizes published studies on transcriptional regulation of selenoprotein genes, focused primarily on genes whose encoded protein functions are at least partially understood. This is followed by in silico analysis of predicted regulatory elements in selenoprotein genes, including those in the aforementioned category as well as

SUBMITTER: Stoytcheva ZR 

PROVIDER: S-EPMC2764002 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature