One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells.

ABSTRACT: Mathematical models are a repository of knowledge as well as research and teaching tools. Although action potential models have been developed for most regions of the heart, there is no model for the atrioventricular node (AVN). We have developed action potential models for single atrio-nodal, nodal, and nodal-His cells. The models have the same action potential shapes and refractoriness as observed in experiments. Using these models, together with models for the sinoatrial node (SAN) and atrial muscle, we have developed a one-dimensional (1D) multicellular model including the SAN and AVN. The multicellular model has slow and fast pathways into the AVN and using it we have analyzed the rich behavior of the AVN. Under normal conditions, action potentials were initiated in the SAN center and

SUBMITTER: Inada S 

PROVIDER: S-EPMC2764063 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature