A practical, two-step synthesis of 2-substituted 1,3-butadienes.

ABSTRACT: A two-step procedure for preparing 2-alkyl-1,3-butadienes is described. Cuprate addition to commercially available 1,4-dibromo-2-butene yields 3-alkyl-4-bromo-1-butene, a product of S(N)2' substitution. Dehydrohalogenation gives 2-alkyl-1,3-butadienes.

SUBMITTER: Sen S 

PROVIDER: S-EPMC2764119 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature