Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies.

ABSTRACT:

Background

Recent studies raised questions about the severity of cognitive impairment associated with dementia with Lewy bodies (DLB). However, there have been few analyses of large, multicenter data registries for clinical-pathologic correlation.

Methods

We evaluated data from the National Alzheimer's Coordinating Center registry (n = 5,813 cases meeting initial inclusion criteria) and the University of Kentucky Alzheimer's Disease Center autopsy series (n = 527) to compare quantitatively the severity of cognitive impairment associated with DLB pathology vs Alzheimer disease (AD) and AD+DLB pathologies.

Results

Mini-Mental State Examination (MMSE) scores showed that persons with pure DLB had cognitive impairment of relatively moderate severity (final MMSE score 15.6

SUBMITTER: Nelson PT 

PROVIDER: S-EPMC2764396 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature