High-sensitivity C-reactive protein predicts mortality but not stroke: the Northern Manhattan Study.

ABSTRACT:

Objective

To determine whether high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (SAA) predict stroke, vascular events, and mortality in a prospective cohort study.

Background

Markers of inflammation have been associated with risk of myocardial infarction (MI). Their association with stroke is controversial.

Methods

The Northern Manhattan Study includes a stroke-free community-based cohort study in participants aged > or =40 years (median follow-up 7.9 years). hsCRP and SAA were measured using nephelometry. Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the association of markers with risk of ischemic stroke and other outcomes after adjusting for demographics and risk factors.

Results

SUBMITTER: Elkind MS 

PROVIDER: S-EPMC2764412 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature