Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures.
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ABSTRACT:
SUBMITTER: Schmidt M
PROVIDER: S-EPMC2764733 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
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Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures.
Schmidt Matthias M Sachse Carsten C Richter Walter W Xu Chen C Fändrich Marcus M Grigorieff Nikolaus N
Proceedings of the National Academy of Sciences of the United States of America 20091020 47
We performed mass-per-length (MPL) measurements and electron cryomicroscopy (cryo-EM) with 3D reconstruction on an Abeta(1-42) amyloid fibril morphology formed under physiological pH conditions. The data show that the examined Abeta(1-42) fibril morphology has only one protofilament, although two protofilaments were observed with a previously studied Abeta(1-40) fibril. The latter fibril was resolved at 8 A resolution showing pairs of beta-sheets at the cores of the two protofilaments making up ...[more]
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