Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses.

ABSTRACT:

Background

Novel methods to identify anthelmintic drug and vaccine targets are urgently needed, especially for those parasite species currently being controlled by singular, often limited strategies. A clearer understanding of the transcriptional components underpinning helminth development will enable identification of exploitable molecules essential for successful parasite/host interactions. Towards this end, we present a combinatorial, bioinformatics-led approach, employing both statistical and network analyses of transcriptomic data, for identifying new immunoprophylactic and therapeutic lead targets to combat schistosomiasis.

Methodology/principal findings

Utilisation of a Schistosoma mansoni oligonucleotide DNA microarray consisting of 37,632 elements enabled gene expr

SUBMITTER: Fitzpatrick JM 

PROVIDER: S-EPMC2764848 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature