Timing of locomotor activity circadian rhythms in Caenorhabditis elegans.

ABSTRACT: Circadian rhythms are driven by endogenous biological clocks and are synchronized to environmental cues. The chronobiological study of Caenorhabditis elegans, an extensively used animal model for developmental and genetic research, might provide fundamental information about the basis of circadian rhythmicity in eukaryotes, due to its ease of use and manipulations, as well as availability of genetic data and mutant strains. The aim of this study is to fully characterize the circadian rhythm of locomotor activity in C. elegans, as well as a means for genetic screening in this nematode and the identification of circadian mutants. We have developed an infrared method to measure locomotor activity in C. elegans and found that, under constant conditions, although inter-individual variability is

SUBMITTER: Simonetta SH 

PROVIDER: S-EPMC2764868 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature