Grb2 signaling in cell motility and cancer.

ABSTRACT:

Background

Metastasis is the primary cause of death in most human cancers, and understanding the molecular mechanisms underpinning this multistep process is fundamental to identifying novel molecular targets and developing more effective therapies.

Objective/methods

Here we review the role of growth factor receptor-bound protein 2 (Grb2) in cancer and specifically in metastasis-related processes, and summarize the development of anticancer therapeutics selectively targeting this adapter protein.

Results/conclusion

Grb2 is a key molecule in intracellular signal transduction, linking activated cell surface receptors to downstream targets by binding to specific phosphotyrosine-containing and proline-rich sequence motifs. Grb2 signaling is critical for cell cycle progress

SUBMITTER: Giubellino A 

PROVIDER: S-EPMC2764957 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature