Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models.

ABSTRACT:

Background

Tumour stromal myofibroblasts can promote tumour invasion. As these cells are genetically more stable than cancer cells, there has been enormous interest in developing targeted molecular therapies against them. Chloride intracellular channel 4 (CLIC4) and reactive oxygen species (ROS) have been linked with promoting stromal cell transdifferentiation in various cancers, but little is known of their roles in ovarian cancer. In this study, we examined the functional roles that both CLIC4 and ROS play in the process of ovarian cancer cell-stimulated or TGF-beta1 induced fibroblast-to-myofibroblast transdifferentiation. We also examine whether it is possible to reverse such a process, with the aim of developing novel therapies against ovarian cancer by targeting activated tra

SUBMITTER: Yao Q 

PROVIDER: S-EPMC2765417 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature