Synthesis and structure of mycolactone E isolated from frog mycobacterium.

ABSTRACT: The structure of mycolactone E, isolated from the frog pathogen Mycobacterium liflandii, was established via organic synthesis. Within the mycolactone family of metabolites, a structural variation has been seen only at the unsaturated fatty acid moiety thus far, and mycolactone E follows this observation. Interestingly, the absolute configuration of its unsaturated fatty acid matches that of the mycolactones from human mycobacteria, rather than the structurally more closely related mycolactone F from fish mycobacteria.

SUBMITTER: Aubry S 

PROVIDER: S-EPMC2765489 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature