Directed carbozincation reactions of cyclopropene derivatives.

ABSTRACT: A diastereoselective procedure has been developed for the Cu-catalyzed addition of diorganozinc reagents to cyclopropene derivatives. Ester and oxazolidinone functions direct the addition of a variety of organozinc reagents with excellent facial selectivity. The resulting cyclopropylzinc reagents can be captured via stereospecific reactions with electrophiles. Cycloprop-2-ene carboxylic esters, which are directly available from the transition-metal-catalyzed reactions of alkynes with alpha-diazo esters, can be utilized directly in carbozincation protocols. Both diastereoselectivity and regioselectivity are high for the carbozincation reactions of 2-alkylcycloprop-2-ene carboxylate esters. The scope of the method is broadened by the ability to utilize organozinc reagents that have been gene

SUBMITTER: Tarwade V 

PROVIDER: S-EPMC2765507 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature