Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease affecting >4,00,000 individuals in the United States. Population and family-based studies have suggested that there is a strong genetic component. Numerous genomic linkage screens have identified regions of interest for MS loci. Our own second-generation genome-wide linkage study identified a handful of non-major histocompatibility complex regions with suggestive linkage. Several of these regions were further examined using single-nucleotide polymorphisms (SNPs) with average spacing between SNPs of approximately 1.0 Mb in a dataset of 173 multiplex families. The results of that study provided further evidence for the involvement of the chromosome 1q43 region. This region is of particular interest giv

SUBMITTER: McCauley JL 

PROVIDER: S-EPMC2765552 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature